You are hereOctober 16, 2020
Neuroprotective Effects of hAFSC-derived Secretome
A new STEM CELLS Translational Medicine article from researchers led by Annamaria Cimini (University of L'Aquila, L'Aquila) and Liborio Stuppia (D'Annunzio University, Chieti‐Pescara, Italy) reports on the potential of the secretome derived from human amniotic fluid stem cells (hAFSCs) as a therapeutic approach to ischemia/reperfusion injury. Castelli and Antonucci et al. found that the hAFSC secretome activated pro‐survival and anti‐apoptotic pathways in an in vitro model, while subsequent analysis of the exosomal microRNA component of the secretome revealed the presence of microRNAs involved in neurotrophin signaling and those related to neuroprotection and neuronal cell death. Overall, the authors highlight the AFSC secretome as a potential means to stimulate neuronal plasticity and ameliorate cognitive loss and neural replacement, and thereby represent a suitable treatment for ischemia/reperfusion injury.