You are here

Neural Crest Stem Cell-like Cells in Melanoma

A new STEM CELLS Translational Medicine review from Johanna Diener and Lukas Sommer (University of Zürich, Switzerland) summarizes the experimental evidence for the re-emergence of neural crest stem cell (NCSC)‐like cells in melanoma, which hijack embryonic programs to acquire advantages regarding tumor initiation and growth, metastatic spread, and eventually therapy resistance. The authors also discuss preclinical efforts to target NCSC‐like melanoma cells to combat drug resistance, an important goal in the field, and improve melanoma therapy.