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Myometrial Cells Activate WNT Signaling in eMSCs

Researchers from the laboratories of William S.B. Yeung and Philip C.N. Chiu (University of Hong Kong, Pokfulam, Hong Kong) recently hypothesized that human myometrial cells provide niche signals regulating the activities endometrial mesenchymal stem‐like cells (eMSCs). In their new STEM CELLS article, Cao et al. report that myometrial cells produce WNT5A to modulate the self‐renewal activities of endometrial stem cells through activation of WNT/β‐catenin signaling. The authors hope that their new findings will lead to the advanced treatment of women with atrophic endometrium or Asherman syndrome by stimulating self‐regrowth of their endometrium.