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MuSC Activation and Regenerative Potential After Denervation

Motor nerve injury can result in organ atrophy, which becomes permanent in the absence/delay of reinnervation. Despite the enormity of the clinical problem, the pathophysiology preventing muscle recovery remains poorly understood. In a new STEM CELLS article, researchers led by Jason H. Pomerantz (University of California, San Francisco, California, USA) report that stem cells within denervated muscle (MuSCs) maintain regenerative capabilities comparable to those in uninjured muscle even after prolonged periods following nerve injury. Wong et al. suggest that future efforts to restore function should focus on signals to induce the intrinsic regeneration and restoration of neuromuscular continuity.