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MSCs and 3D Scaffold Regenerate Bone Defects

A new STEM CELLS Translational Medicine study from the lab of Yang Chai (University of Southern California, Los Angeles, CA, USA) reveals a novel three‐dimensional (3D)‐printed hydroxyapatite tricalcium phosphate scaffold design and describes standardized loading dosages of dental pulp neural crest mesenchymal stem cells (MSCs) or bone marrow aspirate that support the regeneration of high‐quality bone in a critical-size defect in swine. Overall, Johnson et al. believe that this discovery may significantly impact bone regeneration beyond the craniofacial region and ultimately benefit patients who suffer from debilitating critical-size defects.