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MSC Therapy for Diabetes-related Kidney Injury

A previous study demonstrated that mesenchymal stem cells (MSCs) polarized macrophages into an M2 phenotype via improving mitochondrial function, yet the specific mechanism remained unclear. A new study from the lab of Jingqiu Cheng and Yanrong Lu (West China Hospital, Chengdu, China) assessed the potential role of mitochondrial transfer. As reported in STEM CELLS, Yuan et al. found that mitochondrial transfer from MSCs to macrophages restricted inflammation and alleviated kidney injury in diabetic nephropathy mice via PGC‐1α‐mediated mitochondrial biogenesis and PGC‐1α/TFEB‐mediated autophagy. While shedding light on this new immune‐regulatory mechanism, these new findings offer strategies to improve cell‐based therapies or cell‐free therapeutic approaches for inflammation‐related diseases.