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MSC Sheets Suppress Renal Fibrosis

Renal fibrosis treatment strategies have previously employed the intravascular administration of stem cells. Now, a new study from the laboratory of Tatsuya Shimizu (Tokyo Women's Medical University, Shinjuku‐ku, Tokyo, Japan) has revealed that the transplantation of mesenchymal stromal cell (MSC) sheets onto the kidney provide for dramatic therapeutic effects. These included long‐term cell survival, amelioration of kidney dysfunction, vasoprotection, and a reduction in fibrosis when compared with intravenous administration of MSCs. Overall, Imafuku et al. suggest that cell sheet technology could improve stem cell therapy in various aspects and may represent a novel therapeutic approach for various kidney diseases in the future. For more, head over to STEM CELLS Translational Medicine now!