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MSC Properties Rely on Tissue of Origin

Researchers led by Karin Tarte (Université de Rennes, France) recently assessed the influence of tissue of origin on the functional properties of mesenchymal stem cells (MSCs) in a recent STEM CELLS study. Ménard et al. evaluated transcriptomic, phenotypic, and functional features of paired adipose‐derived stem cells (ASCs) and bone marrow‐derived mesenchymal stem cells (BM‐MSCs) expanded from the same donors and analyzed their native purified counterpart. Overall, the authors highlight how imprinting of tissue influences MSC immune properties and propose adipose tissue as a source of MSCs for the treatment of immune‐mediated diseases.