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MSC Priming and Wound Healing

Mesenchymal stem cells (MSCs) can accelerate wound healing; however, the failure of MSCs or MSC‐conditioned medium to function in all cases suggests room for significant improvement. Now, a study from Guozhong Lv (3rd People's Hospital of Wuxi/Wuxi Medical College of Jiangnan University, Wuxi), Changshun Shao, and Yufang Shi (Soochow University, Suzhou, China) suggests that the beneficial paracrine effects of MSCs on wound healing can be enhanced by pretreatment with inflammatory cytokines. Zhu et al. propose tumor necrosis factor‐α and interferon‐γ treatment as a means to improve the therapeutic effect of MSCs in the treatment of skin injuries. For more, see STEM CELLS Translational Medicine now!