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MSC-polarized Macrophages Alleviate Diabetic Nephropathy

While mesenchymal stem cells (MSCs) have been reported to prevent renal injuries via immune regulation in diabetic models, the mechanisms at play remain to be fully elucidated. Reporting in a new STEM CELLS article, researchers led by Yanrong Lu and Younan Chen (West China Hospital, Chengdu, China) establish that the depletion of macrophages abolishes the renal protective role of MSCs. Furthermore, Yuan et al. demonstrate that the adoptive transfer of MSC‐educated macrophages confers renal protection in diabetic nephropathy model mice, while TFEB knockdown in macrophages abolishes these effects. Overall, this exciting study provides both novel insights into MSC‐based immune regulation and scientific evidence for clinical application of MSCs in diabetic nephropathy.