You are here

MSC-induced Immunosuppression in Asthma

In a new STEM CELLS Translational Medicine article, researchers from the laboratory of Patricia Rieken Macedo Rocco (Federal University of Rio de Janeiro, Brazil) demonstrated that while a single dose of therapeutically administered mesenchymal stem cells (MSCs) failed to ameliorate lung remodeling in house dust mite‐induced allergic asthma, multiple doses of MSCs effectively reduced both lung inflammation and remodeling and improved lung mechanics. However, Castro et al. also note that multiple doses of MSCs resulted in immunosuppressive effects, which should be considered during the development of future clinical trials in patients with severe asthma.