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MSC-induced Antibacterial Defense Mechanisms

A new STEM CELLS Translational Medicine article from researchers led by Gerlinde R. Van de Walle (Cornell University, Ithaca, NY, USA) demonstrates that the equine mesenchymal stem cell (MSC) secretome effectively reduces the viability of methicillin-resistant Staphylococcus aureus (MRSA) biofilms in an ex vivo cutaneous wound explant model. Moreover, Marx et al. also report that the MSC secretome actively modulated immune responses of keratinocytes via a CCL2-mediated mechanism. Collectively, this article provides further support for the value of MSC secretome-based treatments for infected wounds.