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MSC-EVs Improve CD34+ Cell Function

Recent research from the lab of Sandra Muntión (IBSAL‐Hospital Universitario de Salamanca, Salamanca, Spain) aimed to analyze changes induced in human CD34+ hematopoietic stem/progenitor cells following treatment with extracellular vesicles derived from mesenchymal stem cells (MSC-EVs). Reporting in STEM CELLS, Preciado et al. established that MSC-EVs downregulated proapoptotic gene expression,  upregulated the expression of genes involved in colony formation and the JAK‐STAT pathway, and increased in vitro clonogenic ability. Importantly, MSC-EVs also improved the four‐week bone marrow lodging ability of CD34+ cells in a standard xenotransplantation model, suggesting that their approach may allow increased hematopoietic engraftment in the clinic.

 Also see the Press Release from the Stem Cells Portal – “Incubation with Extracellular Vesicles Boosts Cells’ Grafting Ability