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MSC-EVS in Hematopoietic Engraftment

The therapeutic effects of mesenchymal stem cells (MSCs), which exert their functions, at least partially, through the secretion of extracellular vesicles (MSC‐EVs), have the potential to support allogeneic hematopoietic stem cell transplantation (HSCT). A STEM CELLS review article from researchers led by Fermín Sánchez‐Guijo (IBSAL‐Hospital Universitario de Salamanca, Spain) now summarizes findings from in vitro studies and preclinical models regarding the potential of MSC‐EVs in the improvement of hematopoietic function. Preciado et al. discuss the potential advantages of MSC-EVs over MSCs themselves and the limitations and uncertainties regarding isolation, characterization, the mechanism of action, and industrial scalability that must be addressed moving forward.