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MSC-EVS in ARDS - A Concise Review

A new STEM CELLS Translational Medicine review article discusses preclinical studies that have studied the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in models of lung injury with acute respiratory distress syndrome (ARDS), a devastating clinical condition with high mortality rate and no pharmacological treatments, in mind. Aswin Abraham and Anna Krasnodembskaya (Queen’s University, Belfast, UK) note that the evidence suggests a potent protective effect of MSC-EVs mediated through variety of mechanisms related to the transfer of EV cargo to recipient cells; however, further research into mechanisms of action, biodistribution, standardization, and biomanufacturing will be required to facilitate clinical translation of this exciting new cell therapy product.