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Modeling Aortic Diseases Using iPSCs

Aortic diseases carry significant morbidity and mortality, pose a worldwide burden to healthcare, and currently lack therapeutic approaches with proven clinical efficacy. Patient‐derived induced pluripotent stem cell (iPSC)-derived in vitro models can mimic the aortic microenvironment and biomechanics and serve as a useful tool for more precise drug selection and the investigation of disease mechanisms. Now, a STEM CELLS Translational Medicine review article from Hao Lai and Chunsheng Wang (Zhongshan Hospital Fudan University, Shanghai, China) summarizes the use of in vitro models in the research of aortic diseases and provides relevant information regarding the development of advanced models using iPSCs.