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miRNA-GPCR Networks and Zebrafish Gonadal Renewal

Recent research from the laboratory of Jizhou Yan (Shanghai Ocean University, Shanghai, China) sought to delineate the regulatory networks controlling gonadal stem cell renewal in zebrafish. Reporting in STEM CELLS, Guo et al. employed genome‐wide transcriptome mining and gonadal microinjections to demonstrate the importance of two GPCR‐regulatory circuits: miR430a‐Sox9a increased the testis spermatogonia reserve and miR218a‐Sox9b increased the ovarian follicle reserve. The team hopes that their new research will aid in the development of novel therapeutic interventions for aging‐related ovarian failure and testicular regression in humans.