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miR‐200 Family Regulates Progenitor Cell Differentiation

A new STEM CELLS study from researchers led by Brad A. Amendt (University of Iowa, USA) reports on the development of a highly specific, effective inhibitor that knocks-down microRNA levels during embryonic development to determine their effect on stem cells, cell proliferation, and differentiation. Sweat et al. employ this inhibitor to demonstrate how the miR‐200 microRNA family acts to compartmentalize an ectodermal stem cell niche by regulating progenitor cell differentiation during development.