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MicroRNA-mediated ESC Cardiac Mesoderm Differentiation

Embryonic stem cells (ESCs) display both self‐renewal and multilineage differentiation capabilities and represent an essential tool for the in vitro study of early embryo development; however, the exact regulatory mechanism of Wnt3 during ESC differentiation remains unclear. In a recent STEM CELLS article, researchers led by Guiying Wang, Jiuhong Kang (Tongji University), and Chenqi Lu (Fudan University, Shanghai, China) report on their exploration of the critical function and regulatory mechanism of the microRNA (miR)‐184/Wnt3 signaling pathway in modulating cardiac mesoderm differentiation of ESCs. While Liu et al. determined miR‐184 as a direct regulator of Wnt3 during ESC differentiation, the team also further enhanced our knowledge regarding the epigenetic regulatory network of ESC differentiation into cardiac mesoderm and cardiomyocytes.