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MicroRNA‐124a Inhibits mESC Endoderm Differentiation

Researchers from the lab of Takahiro Ichiya (Tokyo Medical University, Tokyo, Japan) recently revealed an additional role for miR‐124a in the early development of mouse embryonic stem cells mESCs in a STEM CELLS article. In their study, Liew et al. employed teratomas as an in vivo system to quantitatively assess the functional role of miRNA in lineage specification through gene expression profiling, discovering that miR‐124a negatively regulates endoderm lineage commitment in mESCs while also playing a role in neuronal fate determination.