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Mechanically Activated EV-based Osteogenesis

Bone regeneration requires the osteogenesis of mesenchymal stem cells, with physical loading a potent stimulus driving this process. While osteocytes are mechanosensitive cells that play fundamental roles in coordinating bone mechanoadaptation, the exact mechanisms involved remain poorly understood. Now, a new study from the laboratory of David A. Hoey (Trinity College Dublin, Ireland) demonstrates that osteocytes subjected to fluid shear secrete a distinct collection of factors that enhance stem cell recruitment and osteogenesis. Eichholz et al. identified that these factors are delivered via extracellular vesicles (EVs), demonstrating a novel mechanism of osteocyte‐stem cell communication; therefore, osteocyte‐derived mechanically-activated EVs hold great potential as a novel cell‐free therapy to enhance bone regeneration. For more, see STEM CELLS Translational Medicine now!