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Maturation in hiPSC‐derived Cardiac Muscle

Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) have enormous potential in the modeling of human cardiac function and disease; however, these cells are limited by their physiologic immaturity. Using gene editing, researchers led by Joseph M. Metzger (University of Minnesota, Minneapolis, MN, USA) have now introduced an adult form of a critical contractile protein, cardiac troponin I, into iPSCs before differentiation. Reporting in a recent STEM CELLS article, Wheelwright et al. demonstrate how the expression of cardiac troponin I enables iPSC‐CMs to function in a manner more similar to mature cardiac myocytes. The authors highlight how this novel iPSC‐CM line has relevance in drug discovery, disease modeling, and studies aiming to understand basic human cardiac physiology.