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Magnetic Guidance Improves MSC Therapy

Although the systemic administration of mesenchymal stem cells (MSCs) ameliorates lung inflammation and attenuates fibrosis in experimental silicosis, MSC therapy fails to reverse collagen deposition and granuloma formation. Now, a new STEM CELLS Translational Medicine article from the lab of Patricia R. M. Rocco (Universidade Federal do Rio de Janeiro, Brazil) reports on an MSC magnetization protocol using citrate functionalized magnetic nanoparticles that kept cells viable and endowed them with magnetic responsivity. Silva et al. demonstrate that a more significant number of MSCs remained in the lungs with the aid of magnets, and this associated with enhanced beneficial effects for the treatment of silicosis in mice. Overall, magnetic targeting may be a promising strategy for the enhancement of MSC‐based cell therapies for chronic lung diseases.