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Macrophages at the Nexus of MSC Potency

A new STEM CELLS concise review from Jacques Galipeau (University of Wisconsin in Madison, Madison, Wisconsin, USA) examines the relationship between culture‐adapted mesenchymal stem cells (MSC) and macrophages as a cornerstone of the pharmaceutical effect in resolving inflammatory and tissue injury syndromes in vivo. The contribution of MSC‐borne chemokines (CCL2 in particular) and the recently recognized biological role of CC/CXC chemokine heterodimers found in the MSC secretome as potent immune modulation agents provide novel insights in identifying those cellular attributes of MSCs that are predictive of clinical response.