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Lineage‐specific Induction of Gut Tube Endodermal Cells

Robust parameter design (RPD) is a multifactorial condition screening tool utilized mainly in industry for developing qualified product design and manufacturing processes. In a recent STEM CELLS article from the labs of Keisuke Sekine (National Cancer Center Research Institute, Tokyo) and Hideki Taniguchi (University of Tokyo, Japan), Yasui et al. report on the application of RPD to establish human induced pluripotent stem cell differentiation protocols that specifically induced anterior foregut, hepatic, pancreatic, or mid‐hindgut cells with much-increased efficiency. Overall, the authors note RPD as a promising tool for the efficient optimization of pluripotent stem cell differentiation protocols.