You are hereDecember 13, 2019
Linc1557 Initiates Mouse ESC Differentiation
In a recent STEM CELLS article, researchers from the laboratories of Guiying Wang and Jiuhong Kang (Tongji University, Shanghai, China) elucidated the critical function and regulatory mechanism of the long intervening/intergenic noncoding RNA (linc)1557‐LIF/STAT3 signaling pathway in the modulation of mouse embryonic stem cell differentiation. While Lan et al. determined the critical function of linc1557 in the initiation of mouse ESC differentiation through directly affecting Stat3 mRNA stability, their findings also enhance the broader understanding of lncRNA function in mouse ESC differentiation.