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LINC01133 Promotes CSC-like Traits in TNBC

Recent research highlighting the critical role of the tumor microenvironment in triple‐negative breast cancer (TNBC) development prompted researchers from the lab of Antoine E. Karnoub (Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA) to investigate the interaction of mesenchymal stem cells with TNBC cells. Their findings, published recently in STEM CELLS, reports a role for MSCs in triggering the expression of the long non‐coding RNA LINC01133 in TNBC cells, which stimulates the propagation of cancer‐stem cell‐like phenotypic traits via upregulation of the pluripotency determining factor KLF4.