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Isolating Clinical-grade UCB-EVs

A new STEM CELLS Translational Medicine article from the lab of Joana Simões‐Correia (Exogenus Therapeutics, S.A., Cantanhede, Portugal) describes an optimized process for the isolation of small extracellular vesicles (EVs) from umbilical cord blood mononuclear cells (UCB‐MNC) that allows for large‐scale manufacturing, Good Manufacturing Practices (GMP) compliance, and easy standardization. Cardoso et al. also characterized EVs, which were enriched in anti‐inflammatory and regenerative molecules that promoted angiogenesis, extracellular remodeling, and accelerated skin regeneration in a mouse model of delayed wound healing.