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Ischemic Disease Therapy Using Human iPSCs

Critical limb ischemia is a condition in which tissue necrosis occurs due to arterial occlusion, resulting in limb amputation in severe cases. A recent STEM CELLS Translational Medicine article from researchers led by Jae Ho Kim (Pusan National University, Gyeongsangnam‐do, South Korea) now report on the therapeutic efficacy of induced pluripotent stem cell (iPSC)-derived endothelial cells and vascular smooth muscle cells following their cotransplantation into ischemic tissues of a peripheral artery disease model. Park et al. report that iPSC‐derived smooth muscle cells enhance iPSC‐derived endothelial cells' therapeutic efficacy in peripheral artery disease via an exosome‐mediated paracrine mechanism.