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Insight into HSC Transplantation

In a new STEM CELLS Translational Medicine review article, researchers led by Kathryn S. Potts and Teresa V. Bowman (Albert Einstein College of Medicine, New York, NY, USA) link biomedical researchers and transplantation clinicians by discussing the potential therapeutic implications of recent fundamental hematopoietic stem cell (HSC) research in model organisms. Fraint et al. consider deficiencies in current HSC transplantation practice, which includes problems achieving adequate cell dose for successful and rapid engraftment, the immense inflammatory cascade activation after myeloablation, and the development of graft‐vs‐host disease. Furthermore, the authors discuss recent advances in the field of HSC biology and transplantation made in preclinical models of zebrafish, mouse and non-human primates that could inform emerging practice for clinical application.