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Induced DNA Repair Generates Genetically Stable iPSCs

A key challenge to the clinical application of induced pluripotent stem cells (iPSC) in the accurate modeling and treatment of human pathologies lies in developing a method for the generation of genetically stable cells that reduce long‐term risks. In a new STEM CELLS article, researchers led by Michael J. Edel (Institut Universitari Barraquer, Bellaterra, Spain) report that CYCLIND1 mRNA transfection helps to repair DNA during reprogramming to pluripotency, resulting in a significantly improved genetically stable footprint in human iPSCs. Overall, Alvarez‐Palomo et al. believe that their advance will enable the more accurate and reliable generation of human iPSCs for disease modeling and future clinical applications.