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Increased pH Limits Formation of WPB in hiPSC-ECs

Researchers from the lab of Ton J. Rabelink (Leiden University Medical Center, Leiden, The Netherlands) recently sought to explore the maturity of endothelial cells derived from human induced pluripotent stem cells (hiPSC-ECs) by investigating their ability to express von Willebrand factor (VWF) and formation of Weibel‐Palade bodies (WPBs). Overall, Tiemeier et al. found that metabolic immaturity hampered proper hiPSC-EC function, and the formation of VWF and WPBs required the lowering of the intracellular pH of hiPSC-ECs. For more information on this fascinating new study, head over to STEM CELLS Translational Medicine.