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Immunosuppressive Properties of Perinatal Cells

A recent STEM CELLS Translational Medicine article from the laboratory of Sean V. Murphy (Wake Forest School of Medicine, Winston-Salem, North Carolina, USA) has highlighted the immunosuppressive properties of perinatal cells on Type 1 T helper (Th1) cells and their associated cytokines. Khoury et al. investigated the ability of human stromal cells derived from the amniotic fluid (AFSCs), the placenta (PLSCs), and the bone marrow (BM‐MSCs) to modulate the inflammatory response of in vitro‐stimulated circulating blood‐derived immune cells in the hope of providing a wider understanding of the role of perinatal cells as a potential therapy to target Th1-mediated diseases.