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IGFBPs Enable IGF1-mediated Retina Formation

In vitro models such as retinal organoids provide information regarding the molecular mechanisms that occur during retinal development. Insulin growth factor binding proteins (IGFBPs) regulate cell activity by controlling the interaction of insulin‐like growth factors (IGFs) with their receptors and subsequent signaling processes. In a recent STEM CELLS article from the lab of Majlinda Lako (Newcastle University, Newcastle upon Tyne, UK), Zerti et al. focused on modeling the role of IGFBPs in human retinal organoid development as a means to understand human retinal histogenesis. Their findings now confirm that IGFBPs enable IGF1 function in retinal lamination and photoreceptor development during the differentiation of pluripotent stem cells into retinal organoids.