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Identifying Highly Scalable MSCs

A new study by researchers from the laboratories of Lawrence W. Stanton (Hamad Bin Khalifa University, Doha, Qatar) and Simon M. Cool (A*STAR, Singapore) has recently established that human bone marrow‐derived mesenchymal stem cells (MSCs) containing a genomic deletion of glutathione S‐transferase theta 1 (GSTT1) possess high growth capacity. In their STEM CELLS study, Sathiyanathan et al. report that GSTT1‐null hMSCs display enhanced clonogenicity and longer telomeres and, therefore, GSTT1 can be considered a genomic biomarker of hMSC scalability.