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Human Neural Stem Cell Therapy in Amyotrophic Lateral Sclerosis

A recent STEM CELLS Translational Medicine article from the labs of Angelo L. Vescovi (Fondazione IRCCS Casa Sollievo della Sofferenza) and Letizia Mazzini (Piedmont University, Novara, Italy) described the results of a phase I trial of the feasibility and safety of microtransplanting human neural stem cell lines into the spinal cord of patients with amyotrophic lateral sclerosis. This new study reports that safety of the procedure, with no major deleterious effects over the short or long term. Furthermore, the authors highlight that the experimental design employed provides benefits in terms of enhancing both intra‐ and interstudy reproducibility and homogeneity and now hope to move forward with phase II clinical studies to study increased cell dosages in larger cohorts of patients.