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HSCs as an Osteogenesis Imperfecta Treatment

Long-term treatment drug treatments that increase overall bone strength in osteogenesis imperfecta patients suffer from detrimental side effects. In a new STEM CELLS study, researchers led by Meenal Mehrotra (Medical University of South Carolina, Charleston, SC, USA) unequivocally established that transplanting hematopoietic stem cells (HSCs) can improve clinical outcomes in osteogenesis imperfecta by differentiating into osteoblasts, which lay down normal collagen. Therefore, Kang et al. establish HSC transplantation as a potentially exciting therapy bone repair in osteogenesis imperfecta and other bone diseases (Images - HSCs differentiate to osteoblasts in pOBCol2.3GFP HSC transplanted OI mice).