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How Umbilical Cord MSCs Ameliorate Atopic Dermatitis

The mechanism underlying the therapeutic effects of mesenchymal stem cells (MSCs) in atopic dermatitis remains unclear. Now, a new STEM CELLS study from Kwang‐Won Seo and Kyung‐Sun Kang (Seoul National University, Seoul, South Korea) establishes that the subcutaneous administration of human umbilical cord blood‐derived MSCs (hUCB‐MSCs) alleviates atopic dermatitis in mice by suppressing the secretion of TNF‐α by mast cells via the secretion of TGF‐β. Additionally, Park et al. discovered that TGF‐β secreted from hUCB‐MSCs inhibits IgE secretion by activated B cells via direct and indirect pathways. Overall, these findings suggest a scientific rationale for treating allergic diseases, including atopic dermatitis, with hUCB‐MSCs.