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How Omega-3 PUFAs Impact Breast CSCs

Dysregulated lipid metabolism associates with the growth of cancer stem cells (CSC); however, potential interventions targeting this pathway remain relatively unexplored. A new STEM CELLS article from researchers led by Jing Xuan Kang (Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA) demonstrates that breast CSCs have a distinct fatty acid profile due to the aberrant expression of lipogenic enzymes, which influence self-renewal and proliferative capabilities. Furthermore, Luo et al. report that omega-3 polyunsaturated fatty acids (PUFAs) effectively suppress the self-renewal and growth of breast CSC by downregulating lipogenic enzyme expression. These findings provide a potential therapeutic application of omega-3 PUFAs by targeting fatty acid metabolism in breast CSCs.