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How NGF Signaling Impacts MSC Therapies

Interactions between a myriad of cytokines and their receptors represent a major regulatory mechanism influencing the regenerative potential of mesenchymal stem cells (MSCs). In a recent STEM CELLS Translational Medicine article, researchers led by Jinmin Zhao (The First Affiliated Hospital of Guangxi Medical University, Nanning) and Quanyi Guo (Chinese PLA General Hospital, Beijing, China) provide an overview of the roles of nerve growth factor (NGF) and its receptors in MSCs to potentially identify strategies that will optimize therapeutic effects.