You are here

How Dopamine Regulates Adult Neurogenesis

Parkinson's disease is a major neurodegenerative disease and how the lack of dopamine affects neurogenesis in the ventricular-subventricular zone (V-SVZ) remains unclear. In a new STEM CELLS article, researchers led by José Luis Labandeira-Garcia and Jannette Rodríguez-Pallares (Universidade de Santiago de Compostela, Spain) show that dopamine increases proliferation and generation of neuroblasts in the V-SVZ and that the blockade of angiotensin AT2 receptors suppresses these effects, showing a functional dependence between dopamine and the renin-angiotensin system (RAS). More importantly, Garcia-Garrote et al. establish that the blockade of angiotensin AT1 receptors or stimulation of angiotensin AT2 receptors can counteract the decline in neurogenesis observed in the V-SVZ in animal models of Parkinson's disease.