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How ASCs Repair Ischemic Muscle

A new study from the labs of Xinwu Lu, Zhiyou Peng, and Kaichuang Ye (Shanghai JiaoTong University School of Medicine, China) recently focused on exploring the mechanism of allogeneic adipose‐derived stem cells (ASCs) in critical limb ischemia (CLI) repair. In their new STEM CELLS article, Liu et al. demonstrated the critical role of macrophages in ASC‐mediated ischemic muscle repair and that transplanted ASCs contribute to tissue remodeling by recruiting and polarizing macrophages into an M2 phenotype. Mechanistically, ASC‐derived interleukin 10 (IL‐10), regulated by hypoxia-inducible factor‐1a (HIF‐1a), plays a crucial role in polarization. The results obtained from this study could contribute to the translational application of allogeneic ASCs in ischemic limb repair and aid the understanding of the interaction between stem cells and macrophages under ischemic conditions.