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hiPSC Organoids Model Lung Disorder

A recent STEM CELLS Translational Medicine article from the lab of Shaun M. Kunisaki (Johns Hopkins University School of Medicine, Baltimore, MD, USA) describes the development of a reproducible ex vivo model of lung development using transgene‐free human induced pluripotent stem cells (hiPSCs) generated from fetuses and infants with Bochdalek congenital diaphragmatic hernia. The model allowed the identification of primary cell‐intrinsic and secondary causes of congenital diaphragmatic hernia lung hypoplasia and the association of mechanical compression with alterations in lung organoid epithelial and mesenchymal gene regulation.