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hiPSC-derived Cortical Neurons

Neuronal replacement by stem cell transplantation represents a potential therapy for neurodegenerative diseases. For example, the transplantation of human pluripotent stem cell (hiPSC)‐derived cortical neurons into the stroke‐injured adult rat cortex can improve neurological deficits and induces functional connections with host neurons; however, all studies with human pluripotent stem cell‐derived neurons have employed xenotransplantation. Now, researchers led by Zaal Kokaia (Lund University, Sweden) demonstrate that hiPSC‐derived cortical neurons form functional synaptic networks and differentiate to mature, layer‐specific cortical neurons when implanted onto organotypic cultures of the adult human cortex. Hansen et al. believe that their findings support the clinical translation of hiPSC‐derived cortical neurons for neuronal replacement in human disorders affecting the cerebral cortex. For all the details, see STEM CELLS Translational Medicine now!