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Haplo-HSC And Allogenic MSC For Juvenile SAA

The transplantation of haploidentical hematopoietic stem cells (HSCs) provides a curative option for newly diagnosed juvenile severe aplastic anemia (SAA) patients; however, this treatment approach suffers from a high incidence of graft failure and graft versus host disease (GvHD). Recently, researchers led by Li Ding, Heng‐Xiang Wang (Air Force Medical Center, PLA), and Heng Zhu (Beijing Institute of Radiation Medicine, Beijing, China) evaluated the ability of allogeneic mesenchymal stem cells (MSCs) to support the success of HSC transplants. Reporting in STEM CELLS Translational Medicine, the authors report that data from a cohort of 103 cases have demonstrated that MSC and HSC cotransplantation yields high engraftment, rapid hematopoietic reconstitution, and a low incidence of acute and chronic GvHD.