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GPCR-mediated Regulation of Epidermal Stem Cells

Skin stem cells express a variety of G‐protein coupled receptors (GPCRs), which play central roles in physiological functions and pathological conditions such as cancer and inflammatory diseases. Understanding GPCR signaling may provide important insight into the maintenance of stem cell identity and the approaches stem cells utilize to respond and adapt to microenvironmental changes. Furthermore, since GPCRs are the direct or indirect target of more than one-third of therapeutic drugs, they constitute a gateway for the pharmacological modulation of stem cell activity. Now, in a new STEM CELLS review article, researchers led by Ramiro Iglesias‐Bartolome (National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA) discuss the impact of GPCRs and their signaling partners in skin keratinocyte biology, particularly in the regulation of the epidermal stem cell compartment.