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Gene Editing to Install a Safety Switch in iPSC

The growth of human induced pluripotent stem cell (iPSC)‐derived cell therapies has prompted the need for effective safety measures; however, there currently exists but a few inducible cell “suicide” systems. In a new STEM CELLS Translational Medicine study, researchers led by Aaron J. Carman (InVitro Cell Research LLC, Greater New York Metropolitan Area, NY, USA) now describe the improved design and in vitro and in vivo testing of a novel inducible “suicide switch” safety system for iPSC‐derived cell‐based therapies.