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GARP Promotes ASC Proliferation and Survival

The in vitro expansion of mesenchymal stem cells leads to a decrease in their proliferative and therapeutic capacity, making basic research on factors regulating proliferation of fundamental importance for their successful translation into clinical applications. Now, researchers led by Per Anderson (Universitario Virgen de las Nieves) and Francisco Martin (University of Granada, Granada, Spain) have established the critical nature of glycoprotein A repetitions predominant (GARP) for the proliferation and survival of adipose‐derived mesenchymal stem cells (ASCs) in vitro. Reporting in STEM CELLS Translational Medicine, Carrillo‐Gálvez et al. demonstrated that GARP prevented an aberrant transforming growth factor‐β (TGF‐β) response in ASCs, characterized by oxidative DNA damage and cell death, and induced a productive TGF‐β response that increased their proliferation and resistance to DNA damage.