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GABAergic Interneuron Generation from PSCs

The identification of multiple forebrain "interneuronopathies" featuring neuropsychiatric symptoms and the efficacy of transplants of embryo‐derived interneurons in rodent models of disorders featuring forebrain disinhibition have engendered tremendous interest in deriving cerebral cortical GABAergic interneurons from pluripotent stem cells (PSCs). In a new concise review article in STEM CELLS from researchers led by Stewart A. Anderson (Children's Hospital of Philadelphia/University of Pennsylvania School of Medicine, USA), Fitzgerald et al. consider the progress in this area and discuss the remaining challenges regarding the use of stem cell-derived cortical interneurons in the study and treatment of forebrain disease.