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FZD5 Regulates Human MSC Senescence

Mesenchymal stem cells (MSCs) hold considerable promise for cell therapy; however, their long‐term culture can induce senescence and an associated loss of function. In a recent STEM CELLS study, researchers led by Hideyuki Okano (Keio University School of Medicine, Tokyo, Japan) report that highly functional MSCs specifically express the FZD5 regulatory protein. Harada et al. revealed that FZD5 prevents senescence and preserves multipotency in the most immature, rapidly proliferating MSC subtype, suggesting that FZD5 gene expression may suppress MSC senescence while maintaining stem cell properties during long‐term in vitro culture.